Biological applications of ionophores

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August undefined, 2024

WebBiological applications of ionophores. by B C Pressman. Annual review of biochemistry. Read more related scholarly scientific articles and abstracts. WebApr 6, 2024 · Ionophores transport ions across biological membranes and have wide-ranging applications, but a platform for their rapid development does not exist. We report a platform for developing ionophores from metal-ion chelators, which are readily available with wide-ranging affinities and specificities, and structural data that can aid rational design.

Ionophore - Wikipedia

WebThe Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous … WebAnalogous ionophores have now been synthesized. Unique applications for these compounds are emerging, based either on their selective toxicity or ability to modify … flower delivery perry ga

Biomedical applications of copper ionophores Request PDF

WebPolyether ionophores are complex natural products capable of transporting cations across biological membranes. Many polyether ionophores possess potent antimicrobial activity and a few selected compounds have the ability to target aggressive cancer cells. Nevertheless, ionophore function is believed … WebIonophores are compounds that form lipid soluble, dynamically reversible complexes with cations and by this means facilitate specific ionic transport across biologic membranes (Pressman, 1976; Reed, 1982; Taylor et al., 1982 ). There are two major subclasses of ionophores, (1) neutral ionophores, which are highly toxic because they form charged ... WebAs it has turned out, medical and pharmaceutical applications of ionophores are limited, since the activity of ionophores is not restricted to microbial membranes. On the other … flower delivery penzance

Frontiers Selective Targeting of Cancer Cells by Copper Ionophores ...

Biological Applications of Ionophores Annual Review of …

WebOct 9, 2016 · Biological applications of ionophores. Annu Rev Biochem. 1976; 45:501–530. [Google Scholar] Reiner R, Weiss U, Brombacher U, Lanz P, Montavon M, Furlenmeier A, Angehrn P, Probst PJ. Ro 13-9904/001, a novel potent and long-acting parenteral cephalosporin. J ... WebThe control of ion transport and homeostasis is a critical function of living organisms. In this perspective, an overview of different synthetic systems capable of facilitating the transmembrane transport of ions along with the biological activity exerted by these compounds is presented. Examples of both cat flower delivery penticton bcWebMar 4, 2024 · The development of new therapeutic agents should aim to increase selectivity and therefore reduce side effects. In addition, these agents should overcome cancer cell resistance and target cancer ... flower delivery pequot lakes mn

"WebMay 30, 2013 · Moreover, the discovery of salinomycin and other natural ionophores as CSC-selective drugs opened up the possibility of repurposing these drugs for novel applications in human medicine ... " - Biological applications of ionophores

Biological applications of ionophores

Zinc ionophores: chemistry and biological applications

WebJan 1, 2024 · Biological Applications of Ionophores. Article. Feb 1976; Berton C. Pressman; View. Effects of a low protein diet during pregnancy of the rhesus monkey. I. Reproductive efficiency. Article. WebMay 27, 2024 · Despite several ionophores revealing potential therapeutic applications as apoptosis inducers, ... In the context of transporting molecules of biological relevance, quite a few ionophores have been …

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WebFeb 12, 2024 · Ion-selective electrodes (ISEs) are one of the most established types of chemical sensors, commercialized for a wide variety of applications ranging from their use as indicator electrodes in titrations to the direct determination of ions in clinical analysis. 1 This latter application has been largely aided by the implementation of ionophore-based … WebMar 4, 2024 · Cu ionophores include HQs that have a vast variety of biological applications. The most known compound of the HQ class is 7-iodo- 5-chloro-8-hydroxyquinoline (CQ) that was first used as an antibiotic and more recently has been studied for the repurposing in different diseases ranging from neurodegenerative …

WebNov 1, 2024 · Cu ionophores include HQs that have a vast variety of biological applications. The most known compound of the HQ class is 7-iodo-5-chloro-8-hydroxyquinoline (CQ) that was first used as an ... WebIonophores transport ions across biological membranes and have wide-ranging applications, but a platform for their rapid development does not exist. We report a platform for developing ionophores from metal-ion chelators, which are readily available with wide-ranging affinities and specificities, and structural data that can aid rational design.

WebNatural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to … WebIonophores are a class of compounds that form complexes with specific ions and facilitate their transport across cell membranes. An ionophore typically has a hydrophilic pocket (or hole) that forms a binding site specific for a particular ion. The exterior surface of an ionophore is hydrophobic, allowing the complexed ion in its pocket to cross the …

WebNov 1, 2024 · Copper ionophores alter the concentration, distribution, and reactivity of endogenous copper ions with consequent profound biological repercussions. The …

WebJul 1, 1976 · Ionophores are compounds of moderate molecular weight (about 200-2(00) that form lipid-soluble complexes with polar cations, of which K+, Na+, Ca2+, Mg2+, and … flower delivery peoria arizonaWebThe structure and physical chemical properties are reviewed of various ionophores, small molecules which transport cations across biological membranes. The subclass of carboxylic ionophores has dramatic pharmacological properties, dilating the coronary arteries and increasing cardiac contractility, which make them especially interesting. greek term for hypocriteWebJan 15, 2000 · Monopodal and oligopodal Mg2+-selective ionophores were characterized by their selectivity coefficients (Separate Solution Method, SSM) in plasticized poly ... “Chemical Sensors and Biosensors for Medical and Biological Applications”, 1998, Wiley–VCH, Weinheim. M. Müller, M. Rouilly, B. Rusterholz, M. Maj-Zurawska, Z. Hu, … greek temples sicilyWebBiological applications of ionophores. Pressman BC. Annual Review of Biochemistry , 01 Jan 1976, 45: 501-530 DOI: 10.1146 ... Biological applications and evolutionary origins of ionophores. Pressman BC, deGuzman NT. Adv Exp Med Biol, 84:285-300, 01 Jan 1977 greek term for churchWebPressman BC (1976) Biological applications of ionophores. Ann Rev Biochem 45:501–530. CrossRef PubMed CAS Google Scholar Puskin JS, Gunter TE (1975) Electron paramagnetic resonance of copper ion and manganese ion complexes with the ionophore A23187. Biochemistry 14:187–191 . CrossRef ... greek terms for beautyWebNov 1, 2024 · Ionophores transport ions across biological membranes and have wide‐ranging applications, but a platform for their rapid development does not exist. greek temples vs roman templesWebMay 27, 2024 · A comprehensive investigation of the structure-activity relationships, selectivity aspects and biological implications in terms of potential therapeutic applications of these ionophores will be … greek terms refers to function