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WebSep 25, 2024 · Intrahepatic cholangiocarcinoma (ICC) is a rare but fatal tumor. The isocitrate dehydrogenase 1 and 2 (IDH1/2) genes are known to be mutated in ICC. IDH1/2 mutations tend to be accompanied by ... WebPoint mutation ATM/ATR: Point mutation BRCA1: Point mutation Chk1: Point mutation Chk2: Point mutation DNA-PK: Point mutation FANCs: Point mutation HIPK2: Point mutation NBS1: Point mutation, deletion p53: Point mutation, deletion WT1: Point mutation, deletion MUTYH: Point mutation, deletion BLM: Point mutation, deletion … WebMar 16, 2016 · Introduction. New sequencing technologies have enabled the identification of several mutations in epigenetic regulator genes, such as Ten-eleven-translocation 2 (TET2), which encodes an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC).Mutations in the coding regions of TET2 lead to loss of … the handmade ice cream company greenodd