WebIntroduction. As a recognized food-grade preservative, sodium benzoate (SB), whose structure is shown in Fig. 1, is widely used in the food, cosmetic, and pharmaceutical industries [1–3].For example, in the food industry, SB is used in a variety of foods and beverages, such as salads, kimchi, carbonated beverages, jams, juices, and soy sauce, … WebWith the aim to identify other lysosomotropic drugs with possible inherent antiviral activity, we have applied a set of clear physicochemical, pharmacokinetic and molecular criteria …

Widely available lysosome targeting agents should be ... - PubMed

WebLysosomal exocytosis is also perturbed in a variety of lysosomal and lipid storage disorders (reviewed in Samie and Xu, 2014;Settembre and Ballabio, 2014), and lysosomal exocytosis can drive the... WebLysosomotropic agents include kinase inhibitors such as ML-9, 179 metal nanoparticles (NPs), 180 and some pharmaceutically important drugs, which include nortriptyline, siramesine, desipramine, clomipramine, imipramine, etc. 48 The chemical structure of some of these compounds is listed in Figure 4. lithium reddit

Neurobiology of Disease

Web12 apr. 2011 · Lysosomotropic agents (LA) such as Chloroquine and Ammonium chloride (NH 4 Cl) are the weak bases and penetrate in lysosome as protonated form and … Web22 nov. 2013 · It is well documented that lysosomotropic agents can trigger lysosomal membrane permeabilization [52,53]. We have previously shown that the cell death associated with lysosomotropic compounds can be rescued by Bafilomycin A, which increases lysosomal pH and prevents compound accumulation, further supporting … Web10 mrt. 2024 · Pharmaceutical lysosomotropic agents include the antidepressants siramesine, nortriptyline, desipramine, imipramine, and clomipramine [ 19 ]. These have shown effectiveness in breast cancer, colon cancer, and CLL cells. Antimalarials mefloquine and chloroquine have shown effectiveness in breast cancer, lymphoma, and leukemia … lithium redarc