Webb1 sep. 2024 · 2024-03-10, AD 2024 nr 10. Fråga om avskedande och om en anställd hos Arbetsförmedlingen bl.a. har gjort sexuella närmanden mot en arbetssökande, såväl fysiskt som verbalt, och utlovat förmåner till henne i utbyte mot en sexuell relation. Domstolen har funnit påståendena styrkta och att det därmed funnits skäl för avskedandet. PLD3 is highly expressed in the brain in both humans and mice, and is mainly localized in the endoplasmic reticulum (ER) and the lysosome . PLD3 may play a role in regulating the lysosomal system, myogenesis, late-stage neurogenesis, inhibiting insulin signal transduction, and amyloid precursor protein (APP) … Visa mer Phospholipase D3, also known as PLD3, is a protein that in humans is encoded by the PLD3 gene. PLD3 belongs to the phospholipase D superfamily because it contains the two HKD motifs common to members of the … Visa mer PLD3 was first characterized as a human homolog of the HindIII K4L protein in the vaccinia virus, having a DNA sequence 48.1% similar to the viral gene. The PLD3 gene in humans is located at chromosome 19q13.2, with a sequence comprising at least 15 Visa mer PLD3 is a member of the phospholipase D protein family, however, unlike phospholipase PLD1 and PLD2, it serves as a 5' exonuclease that specifically degrade ssDNA in the endolysosome, which is similar to the function of PLD4. Both PLD3 and PLD4 are … Visa mer Alzheimer's disease Mutations in PLD3 have been studied for their potential role in the pathogenesis of late-onset Alzheimer's disease Visa mer PLD3 is a 490 amino acid-long type 2 transmembrane protein, unlike PLD1 and PLD2 which do not contain a transmembrane protein domain in their protein structure. Visa mer Expression of PLD3 in tissues differs with the transcript size of its mRNA. The longer 2200 base pair transcript is ubiquitously expressed in the body, exhibiting higher expression levels in the heart, skeletal muscle, and the brain. Meanwhile, the shorter 1700 base … Visa mer The human progranulin protein (PGRN), encoded by the human granulin gene (GRN), is co-expressed with and interacts with PLD3 accumulated on neuritic plaques in AD brains. … Visa mer
Epigenetic dysregulation of enhancers in neurons is associated …
Webb21 juli 2015 · Our current meta-analysis showed that PLD3 V232M confers susceptibility to AD at a moderate effect size (OR = 1.53), indicating a susceptibility role rather than a … Webb17 apr. 2015 · More than a year ago, researchers identified variants in phospholipase D3 (PLD3) as risk factors for Alzheimer’s disease. First found in two families and then … moving finger cast 2006
Nature 复旦大学袁鹏等发现损害阿尔茨海默症中神经网络功能的 …
Webb67967 Ensembl ENSG00000077514 ENSMUSG00000030726 UniProt Q15054 Q9EQ28 RefSeq (mRNA) NM_006591 NM_001363597 NM_133692 NM_001368380 RefSeq … Webbfor Understanding the role of APP, PSEN1, PSEN2, TREM2, and PLD3 in AD Research Categorization Primary Disease / Condition Alzheimer's Disease CADRO Category A. Molecular Pathogenesis and Physiology of Alzheimer's Disease and Alzheimer's Disease-related Dementias (AD/ADRDs) 17. Genetics g. Disease Pathway Identification Webb26 jan. 2024 · We investigated the effect of genetic deletion of Pld3 on APP proteolysis. mRNA levels of App and different candidate genes, including Adam10, Bace1 and the γ … moving finger youtube