Splet27. dec. 2024 · In general, critically short telomeres eventually lead to cell senescence or apoptosis, limiting the regenerative capacity of tissue [41,42]. Furthermore, mice with AT2 cell dysfunctional telomeres showed impaired response to induced injury . In IPF an increase of apoptosis and senescence signaling has been reported in fibrotic areas. Splet19. jul. 2024 · Genetic studies uncovered mutations in telomere-related genes (TRGs) in individuals with IPF, and these mutations were associated with abnormally short …
Frontiers Transcriptional and Proteomic Characterization of …
Splet05. avg. 2024 · The genetic causes of short telomere syndromes Familial cancers caused by telomere-lengthening mutations Germline mutations in TERT and shelterin are telomere-lengthening Different TPP1 mutations cause distinct disease phenotypes Long telomere–associated SNPs increase cancer risk Splet12. dec. 2024 · Short telomeres are histologically associated with CS markers in IPF patients [29]. An important observation in IPF is shortening of telomeres in about 10% of IPF patients, which has implications ... bonaire vsm75
Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary
Splet26. nov. 2013 · Telomeres, DNA-protein structures at chromosome ends, shorten with age, and telomere length has been linked to age-related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescence, but whether the shortest telomeres are also the best biomarker of ageing is not known. SpletIPF and chronic obstructive pulmonary disease (COPD), a disease with similar demographics and shared risk factors. Using mendelian randomisation, we investigated evidence supporting a causal role for short telomeres in IPF and COPD. Methods . Mendelian randomisation inference of telomere length causality was done for IPF (up to … Splet07. jan. 2024 · Rationale A subset of patients with idiopathic pulmonary fibrosis (IPF) contains short leukocyte telomeres or telomere related mutations. We previously showed … bonaire tui chogogo